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KMID : 0608519960020010205
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Korean Journal of Oriental Medicine
1996 Volume.2 No. 1 p.205 ~ p.225
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The effect of Youngyanggaksan on the anticonvulsive, antipyretic, analgesic, sedative and GABAergic system
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Abstract
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This study has been carried out to investigate the effects of Youngyanggaksan (YGS) extract on the anticonvulsive, antipyretic, anlgesic, sedative and GABAergic system of experimental animals.
@ES The results of this study were as follows :
@EN 1. YGS extract prolonged significantly the beginning time to convulsion and time to death induced by strychnine.
2. YGS extract prolonged significantly the time to death induced by electrical shock of ECT unit (3sec, 200F, 25mA).
3. On the experiment of hypothermic effects of YGS extract on the rectal temperature of rats, YGS extract decreased significantly the rectal temperature of rats.
4. On the experiment of antipyretic effects of YGS extract on the febrile induced by the subcutaneous injection of 150 g/kg endotoxin in rats, YGS extract decreased significantly the rectal temperature of rats.
5. On the experiment of analgesic effects of YGS extract on the writhing syndrome induced by intraperitoneal injection 0.7% acetic acid 1ml/100g in rats, the writhing syndrome was reduced significantly by administration of YGS extract.
6. On the experiment of sedative effects of YGS extract on spontaneous motor activity measured by wheel cage method in mice, the spontaneous motor activity was reduced significantly by administration of YGS extract.
7. On the experiment of effects of YGS extract on the activity of GABA-transaminase(GABA-T) in rat brains after 21 days of oral dministration of YGS extract, the activity of GABA-T was reduced significantly by
administration of YGS extract.
8. On the experiment of effects of YGS extract on the activity concentration of GABA in rat brains after 21 days of oral administration of YGS extract, the activity concentration of GABA was reduced significantly by administration of YGS
extract.
9. On the experiment of effects of YGS extract on the activity of GAD in rat brains after 21 days of oral admistration of YGS extract, the activity of GAD was reduced significantly by administration of YGS extract.
According to the those results, Youngyanggaksan extract reveals the effects on the
anticonvulsive, antipyretic, anlgesic. Sedative and GABAergic system.
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